| Autor: |
Boteanu, Alina, Leon, Leticia, Pérez Esteban, Silvia, Rabadán Rubio, Elena, Pavía Pascual, Marina, Bonilla, Gema, Bonilla González-Laganá, Carmen, García Fernandez, Antia, Recuero Diaz, Sheila, Ruiz Gutierrez, Lucia, Sanmartín Martínez, José Javier, de la Torre-Rubio, Natalia, Nuño, Laura, Sánchez Pernaute, Olga, del Bosque, Iván, Lojo Oliveira, Leticia, Rodríguez Heredia, José Manuel, Clemente, Daniel, Abasolo, Lydia, Bachiller-Corral, Javier |
| Předmět: |
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| Zdroj: |
Modern Rheumatology; Jan2024, Vol. 34 Issue 1, p97-105, 9p |
| Abstrakt: |
Objectives: The aim of this study is to evaluate risk factors for severe coronavirus disease 2019 (COVID-19) in patients with immune-mediated rheumatic diseases, stratified by systemic autoimmune conditions and chronic inflammatory arthritis. Methods: An observational, cross-sectional multicentre study was performed. Patients from 10 rheumatology departments in Madrid who presented with severe acute respiratory syndrome coronavirus-2 infection between February 2020 and May 2021 were included. The main outcome was COVID-19 severity (hospital admission or mortality). Risk factors for severity were estimated, adjusting for covariates (socio-demographic, clinical, and treatments), using logistic regression analyses. Results: In total, 523 patients with COVID-19 were included, among whom 192 (35.6%) patients required hospital admission and 38 (7.3%) died. Male gender, older age, and comorbidities such as diabetes mellitus, hypertension, and obesity were associated with severe COVID-19. Corticosteroid doses >10 mg/day, rituximab, sulfasalazine, and mycophenolate use, were independently associated with worse outcomes. COVID-19 severity decreased over the different pandemic waves. Mortality was higher in the systemic autoimmune conditions (univariate analysis, P < .001), although there were no differences in the overall severity in the multivariate analysis. Conclusions: This study confirms and provides new insights regarding the harmful effects of corticosteroids, rituximab, and other therapies (mycophenolate and sulfasalazine) in COVID-19. Methotrexate and anti-tumour necrosis factor therapy were not associated with worse outcomes. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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