| Abstrakt: |
Osteoporosis is a systemic disease that affects the mineral density of bones and their structure, which leads to an increase in the softness of the bones. One in three women after the age of fifty worldwide is affected. Both breast cancer and osteoporosis are common diseases in women. (The cancer cells of the breast consider a public type of cancer in females, with (1) in (8) females developing breast cancer in their lifetime.) The study aimed to the evaluation of some biomarkers of osteoporosis in women with breast cancer represented by cathepsin K, parathyroid hormone, calcium and vitamin D. The current study was conducted at the National Cancer Center in Al-Najaf province for the period from 15/8/2022 to 20/1/2023. The study included 60 women with breast cancer and 30 healthy women free of diseases, and it was considered a control group. (The ages of patients and healthy people ranged between (30-68) year old,) vitamin D, calcium, parathyroid hormone, and cathepsin K were evaluated. The finding showed no variance (p>0.05) among the two groups under study. The results a significant increase after the statistical analysis (p<0.0001) in the levels of calcium (Ca) and cathepsin K in infected women compared with healthy women. Likelihood (p < 0.005) and calcium with a probability level (p < 0.0001).In conclusion, the current study concludes that there is a high rate of osteoporosis in women with breast cancer. Prevalent. Also, rise in values of calcium in women with breast cancer, with no difference in parathyroid hormone, which is the most important biomarker for breast cancer diagnosis. An increase in the level of cathepsin K and its negative effect on the level of calcium in women that have breast cancer. [ABSTRACT FROM AUTHOR] |
