Study Results from University of Birmingham Provide New Insights into B-Cell Lymphoma (The Oncogenic Lipid Sphingosine-1-Phosphate Impedes the Phagocytosis of Tumor Cells by M1 Macrophages in Diffuse Large B Cell Lymphoma).

Předmět:	B cell lymphoma PHAGOCYTOSIS MACROPHAGES LYMPHOMAS CONNECTIVE tissue cells MANTLE cell lymphoma
Zdroj:	Immunotherapy Weekly; 2/20/2024, p2293-2293, 1p
Abstrakt:	A recent study conducted by researchers at the University of Birmingham in the United Kingdom has provided new insights into diffuse large B-cell lymphoma (DLBCL). DLBCL is a type of B-cell lymphoma that affects a significant percentage of patients who do not respond to standard therapy or experience disease recurrence. The study focused on the role of the lipid sphingosine-1-phosphate (S1P) in the activity of macrophages in DLBCL. The researchers found that tumor-derived S1P attracts monocytes and macrophages, but inhibits the phagocytosis of DLBCL tumor cells by M1 macrophages. They suggest that the administration of S1P receptor 1 (S1PR1) inhibitors could enhance tumor cell phagocytosis and improve patient outcomes. [Extracted from the article]
Databáze:	Complementary Index
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