Association of the C allele of rs479200 in the EGLN1 gene with COVID-19 severity in Indian population: a novel finding.

Autor: Harit, Renuka, De, Sajal, Singh, Piyoosh Kumar, Kashyap, Deepika, Kumar, Manish, Sahu, Dibakar, Yadav, Chander Prakash, Mohan, Mradul, Singh, Vineeta, Tomar, Ram Singh, Pandey, Kailash C., Vashisht, Kapil
Zdroj: Human Genomics; 1/30/2024, Vol. 18, p1-6, 6p
Abstrakt: The present study investigated two single nucleotide polymorphisms (SNPs)—rs479200 and rs516651 in the host EGLN1/PHD2 gene for their association with COVID-19 severity. A retrospective cohort of 158 COVID-19 patients from the Indian population (March 2020 to June 2021) was enrolled. Notably, the frequency of C allele (0.664) was twofold higher than T allele (0.336) in severe COVID-19 patients. Here, we report a novel finding that the C allele of rs479200 in the EGLN1 gene imparts a high risk of severe COVID-19 (odds ratio—6.214 (1.84–20.99) p = 0.003; 9.421 (2.019–43.957) p = 0.004), in additive inheritance model (adjusted and unadjusted, respectively). [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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