| Abstrakt: |
The production of bonelike apatite is necessary. For artificial materials to form direct bonds with the natural bone. In vitro, apatite production may be measured using a simulated bodily fluid (SBF) with identical inorganic ion contents to human blood plasma. The ceramic nanocomposite (ZrO2:MgO) was prepared using the sol-gel method by dissolving precursor materials with equal mixing ratios, molar concentration, and constant reaction temperature. The ceramic nanocomposite was calcined at 1000°C 4 hours. In this study, it was found that the ceramic nanocomposite after soaking for 30 days in the simulated body fluid. The results were obtained using X-ray analysis to study the crystal structure formation of polycrystalline phases of(ZrO2:MgO), with an average crystallite size of (13.5 nm). After immersing the ceramic nanocomposites in SBF, the X-ray analysis showed that a new phase of calcium phosphate was formed on the surface of the ceramic nanocomposites. The Surface morphology and particle size were obtained using an FE-SEM, where it was found that the average particle size (22-39 nm) and the shape of the particles was spherical and with a dendritic shape which Provided a high opportunity for growth of the layer Hydroxyapatite flacks on the surface of a ceramic nanocomposite with the form of a turtle shell after immersion in SBF. This result is confirmed by the energy X-rays diffraction (EDX) technique, which showed the formation of absorption peaks, ensuring the appearance of Zr (ZrKα1), Mg (MgLα1), P (PKα1), Ca (CaKα1) and oxygen (OKα1) for elements. The result of the cytotoxicity assay by culturing the ceramic nanocomposite at known concentrations outside the body with human cells of the osteosarcoma cell line type (MG-63) showed no cytotoxic effects. The results of the Nanocomposite injected using the biopolymer (PLA) inside the fractured bone were positive, as, through the examination, it was found that the hydroxyapatite substance was densely formed on the injected material and the tissue bonding on the injection site. Therefore, ceramic Nanocomposites can be used in bone and artificial bone restoration applications because they have biocompatibility properties, which is an essential factor in the growth of hydroxide on the surfaces of specimens, which is mainly involved in building and repairing bones in vivo. [ABSTRACT FROM AUTHOR] |
