| Autor: |
Kaneda, Yuto, Kanemura, Nobuhiro, Nakamura, Nobuhiko, Ikoma, Yoshikazu, Yamaguchi, Kimihiro, Takada, Eri, Shibata, Yuhei, Lee, Shin, Fujita, Kei, Morishita, Tetsuji, Matsumoto, Takuro, Nakamura, Hiroshi, Kitagawa, Junichi, Kasahara, Senji, Hara, Takeshi, Tsurumi, Hisashi, Shimizu, Masahito |
| Předmět: |
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| Zdroj: |
Leukemia & Lymphoma; Mar2024, Vol. 65 Issue 3, p339-345, 7p |
| Abstrakt: |
Predicting prognosis is crucial in older patients with diffuse large B-cell lymphoma (DLBCL). This study evaluated the prognostic impact of the controlling nutritional status (CONUT) score, a simple nutritional index, for older DLBCL patients (≥65 years of age) treated with R-CHOP-like regimens in a retrospective, cohort study including 203 patients. The CONUT score was an independent prognostic factor for overall survival (hazard ratio 1.11, 95% confidence interval (CI) 1.01-1.21, p = 0.032) in a multivariable Cox proportional hazards model. On receiver-operating characteristic analysis, the optimal cutoff value was 3. The CONUT score (≥3 or <3) effectively stratified older DLBCL patients, regardless of the International Prognostic Index (p = 0.71 for interaction). Further, the CONUT score independently affected initial dose intensity (odds ratio 0.84, 95% CI 0.73-0.95, p = 0.008), likely reflecting the patients' status at diagnosis and affecting dose adjustments. In conclusion, the CONUT score is associated with a poorer prognosis in older DLBCL patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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