| Autor: |
Doğu, Hüseyin, Muçuoğlu, Ali Osman, Aygün, Demet, Demirel, Nail, Akdemir, Hidayet |
| Předmět: |
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| Zdroj: |
Journal of Turkish Spinal Surgery; 2024, Vol. 35 Issue 1, p31-37, 7p |
| Abstrakt: |
Objective: Spontaneous or low-energy vertebral compression fractures are encountered in clinical practice and pose a diagnostic challenge. This study aimed to determine the role of systemic inflammatory markers in the differential diagnosis of malignant and osteoporotic vertebral fractures (MVF and OVF). Materials and Methods: Patients who underwent surgical treatment for OVF and MVF at our center were retrospectively analyzed. Neutrophilto-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic inflammatory index (SII) values were calculated using complete blood count data obtained before treatment. Optimal cut-off values were determined for the differentiation of OVF and MVF. The results were correlated with the histopathological and surgical findings. Results: The study was conducted with 72 patients, 73.6% (n=53) of whom were women and 26.4% (n=19) were men. Of the patients participating in the study, 63.9% (n=46) had OVF and 36.1% (n=26) had MVF. The mean age of the OVF group (69.93±15.52) was significantly higher than that of the MVF group (56.38±19.76) (p=0.001; p<0.01). Furthermore, the ratio of women in the OVF group (84.8%) was significantly higher than that in the MVF group (53.8%) (p=0.006; p<0.01). The lymphocyte measurements of the MVF group were significantly lower than those of the OVF group (p=0.029; p<0.05). The PLR (p=0.026; p<0.05), NLR (p=0.009; p<0.01), and SII (p=0.007; p<0.01) measurements were significantly higher in the MVF group than in the OVF group. Conclusion: Our study found significantly elevated levels of inflammatory markers (NLR, PLR, SII) in MVF compared with OVF. These findings suggest that NLR, PLR, and SII hold promise as concise and effective tools for the differential diagnosis of low-energy vertebral compression fractures. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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