| Autor: |
Roy, Madhuparna, Dey, Abhishek, Dey, Somdatta Ghosh |
| Zdroj: |
Chemical Communications; 2/18/2024, Vol. 60 Issue 14, p1940-1943, 4p |
| Abstrakt: |
Heme bound Aβ peptides have been reported to reduce O2 by 2e− to H2O2 which may result in oxidative stress commonly encountered in Alzheimer's disease. In this study we report the first instance of rapid freeze quench trapping and characterizing the heme(III)-O2˙− intermediate involved in the heme-Aβ induced formation of partially reduced oxygen species (PROS) in physiologically relevant aqueous medium using absorption and resonance Raman spectroscopy. The kinetics of this process indicates a key role of the Tyr10 residue, unique to human Aβ, in the generation of H2O2 from O2. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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