| Autor: |
Safari‐Faramani, Roya, Salehi, Mohsen, Ghambari Haji Shore, Saman, Omidpanah, Neda |
| Předmět: |
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| Zdroj: |
Clinical & Experimental Dental Research; Feb2024, Vol. 10 Issue 1, p1-7, 7p |
| Abstrakt: |
Objectives: Recurrent aphthous stomatitis (RAS) is an ulcerative condition with unknown etiology. The effect of vitamin D in the etiology of RAS is still a matter of controversy. In this study, we aimed at review the available evidence on the role of vitamin D deficiency in RAS etiology. Material and Methods: PubMed, Cochrane Library for Systematic Reviews, ISI Web of Science, Scopus, and EmBase were systematically searched for evidence on RAS and vitamin D up to January 2020. Retrieved records were screened and assessed by two of the authors independently. Newcastle−Ottawa scale was used to assess the quality of individual studies. AMSTAR tool was used for assessing the quality of the study. Results: Eight studies including 383 healthy control and 352 patients with RAS were eligible for the meta‐analysis. Serum vitamin D levels were significantly lower in RAS patients. The weighted mean difference was −7.90 (95% CI: −11.96 to −3.85). Conclusions: The results highlighted the importance of vitamin D deficiency in the etiology of RAS. However, more studies are needed to reach a robust decision. The observed association between vitamin D and RAS is probably due to the effect of vitamin D on the immune system. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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