| Abstrakt: |
Objectives] To explore the anti-tumor activity of the extracts of petroleum ether, ethyl acetate, n-butanol and aqueous solution from Mahoniae caulis. [Methods] The extracts were extracted with petroleum ether, ethyl acetate, n-butanol and aqueous solution respectively, and then concentrated. The inhibitory effects of these extracts on the growth of three tumor cell lines in vitro were detected by CCK-8 meth- od, and the IC value was calculated. [Results] The four extracts inhibited the growth of the three tumor cell lines in vitro, among which the n-butanol extract had the best anti-tumor activity. The ICs values of the n-butanol extract on human gastric cancer (SGC-7901), human breast cancer (MCF-7) and human liver cancer (BEL-7404) cell lines were 0.23, 0.25 and 0.58 mg/mL, respectively. [Conclusions] The ethanol extract of Mahoniae caulis under petroleum ether, ethyl acetate, n-butanol and aqueous solution had certain anti-tumor effect, and n-butanol extract had the best anti-tumor activity. [ABSTRACT FROM AUTHOR] |
