Overcoming NMR line broadening of nitrogen containing compounds: A simple solution.

Autor:	Ma, Junhe, Ye, Qingmei, Green, Rebecca A., Gurak, John, Ayers, Sloan, Huang, Yande, Miller, Scott A.
Předmět:	SPECTRAL line broadening CONFORMATIONAL isomers NITROGEN compounds MORPHOLINE ISOMERIZATION TAUTOMERISM
Zdroj:	Magnetic Resonance in Chemistry; Mar2024, Vol. 62 Issue 3, p198-207, 10p
Abstrakt:	This study presents a straightforward solution to the challenge of elucidating the structures of nitrogen containing compounds undergoing isomerization. When spectral line broadening occurs related to isomerization, be it prototropic tautomerism or bond rotations, this poses a significant obstacle to structural elucidation. By adding acids, we demonstrate a simple approach to overcome this issue and effectively sharpen NMR signals for acid stable prototropic tautomers as well as the conformational isomers containing a morpholine or piperazine ring. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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