| Abstrakt: |
This study aimed to investigate the protective effects of usnic acid and alpha lipoic acid on changes in cellular mitogenic activity proteins in serum, liver, and kidney tissue of rats with cadmium toxicity. Cadmium (Cd) amounts in samples taken from serum, liver and kidney tissues, and Mitogen Activity Protein Kinases (MAPK), Guanosine Triphosphatase (GTPase), Nuclear Factor Kappa-B P65 (NFκBp65) and Nuclear Factor Kappa-B (NFκB) in cell and mitogenic activity proteins in liver and kidney tissues changes were evaluated. The levels of Cd in liver and kidney tissues increased significantly compared to control, whereas liver Cd levels of usnic acid (UA) group decreased. MAPK activity in liver tissues of alpha lipoic acid (ALA) group showed a statistically significant decrease compared to other groups. In contrast, liver tissues of UA group showed a significant increase compared to all other groups. Renal tissue GTPase level decreased significantly in the control group compared to the other groups, while GTPase level was increased dramatically in UA group compared to all other groups. When the levels of NF-κBp65 protein in liver tissue were compared to control, Cd increased significantly. In contrast, comparison of Cd group to UA + Cd and ALA + Cd groups showed a significant decrease in NF-κBp65 levels. Application of ALA in Cd toxicity significantly increased liver tissue NF-κB levels and decreased renal tissue NF-κB levels. In conclusion, it was determined that UA and ALA have protective effects on Cd-induced liver toxicity in rats. In contrast, UA and ALA did not have a protective effect on renal tissue. [ABSTRACT FROM AUTHOR] |
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