| Autor: |
Nutan Tudu, Sarkar, Aniket, Mondal, Sayan, Bandyopadhyay, Bidyut, Sundar Panja, Anindya |
| Předmět: |
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| Zdroj: |
Biology Bulletin; 2023 Suppl 3, Vol. 50, pS310-S316, 7p |
| Abstrakt: |
p53 is a transcription factor, which is encoded by the TP53 gene in human. p53 regulates the cell cycle and functions as a tumour suppressor, thus, involved in preventing cancer. In vivo, analysis of p53 mechanisms in whole animal models are critical, alternatively Drosophila can be selected. Our present study worked on comparative and interactome profiling of p53 protein using PyMol and Haddock 2.4. The structural similarity resulted that p53 of Drosophila (Dmp53) is almost alike to that of human p53 (Hp53) protein. Hp53 interacting proteins were systematically docked and analyzed with Hp53 and Dmp53 both. Furthermore the associated complexes are analysed through Discovery Studio. The interactome study revealed better homologous interaction like human p53. Drosophila p53 exhibits characteristics that makes it a promising model for cancer research, bearing resemblance to human p53. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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