| Autor: |
Antonov, E. N., Ivanova, A. G., Krotova, L. I., Mishakov, G. V., Popov, V. K. |
| Zdroj: |
Russian Journal of Physical Chemistry B: Focus on Physics; Dec2023, Vol. 17 Issue 8, p1555-1560, 6p |
| Abstrakt: |
Micronization of the pharmaceutical substance levofloxacin hemihydrate (LFC) was studied by the RESS method with trifluoromethane (CHF3) as a polar supercritical solvent. Scanning electron microscopy showed that, at a CHF3 temperature of 50°C, particles of micronized LFC have the shape of microgranules of submicron size. At a temperature of 100°C, the particles take the shape of thin (less than 0.1-μm-thick) elongated plates with rounded edges. At this temperature, an increase in the CHF3 pressure from 20 to 35 MPa leads to an increase in the average particle size from 1 to 2 μm, respectively. X-ray powder diffraction analysis of samples obtained at a temperature of 50°C determined the identity of the original and micronized LFC substances, which correspond to the structure of levofloxacin hemihydrate C36H40F2N6O8⋅H2O. An increase in the process temperature to 100°C leads to the formation of one of pseudopolymorphs of levofloxacin—levofloxacin monohydrate C18H20F2N3O4⋅H2O—in the micronized LFC. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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