| Abstrakt: |
Researchers from the University of Antioquia in Colombia have discovered a short antimicrobial peptide (AMP) derived from the venom gland transcriptome of the spider species Pamphobeteus verdolaga. The AMP, named PvAMP66, demonstrated broad-spectrum antimicrobial properties and showed activity against multidrug-resistant strains of Klebsiella pneumoniae. The researchers also found that PvAMP66 had an additive interaction with the antibiotic gentamicin, leading to a ten-fold reduction in its effective concentration. Further pre-clinical studies are needed to explore the potential of PvAMP66 as an active pharmaceutical ingredient in combination therapy. [Extracted from the article] |
