Data from Dana-Farber Cancer Institute Advance Knowledge in Chemicals and Chemistry (Covalent Inhibition of Pro-apoptotic Bax).

Předmět:
Zdroj: Health & Medicine Week; 2/16/2024, p1256-1256, 1p
Abstrakt: A new report from the Dana-Farber Cancer Institute in Boston, Massachusetts discusses the potential therapeutic targeting of the BCL-2-associated X protein (BAX) in diseases involving abnormal cell survival or death. The researchers identified a compound called covalent BAX inhibitor 1 (CBI1) that interacts with BAX and inhibits its activation. This discovery provides insights into a pharmacologic strategy for suppressing unwanted cell death in various diseases. The research has been peer-reviewed and published in Nature Chemical Biology. [Extracted from the article]
Databáze: Complementary Index