Global brain analysis of minor hallucinations in Parkinson's disease using EEG and MRI data.
Autor: | Chuan Liu, Liangcheng Qu, Qixue Li, Yiting Cao, Jingping Shi, Chao Yu, Weiguo Liu, Kuiying Yin |
---|---|
Předmět: |
HALLUCINATIONS
BRAIN FRONTAL lobe ELECTROENCEPHALOGRAPHY NEURAL pathways MAGNETIC resonance imaging MACHINE learning PARKINSON'S disease VISUAL perception SIGNAL processing RESEARCH funding DATA analysis ARTIFICIAL neural networks VISUAL evoked response MENTAL illness CEREBRAL cortex DISEASE complications |
Zdroj: | Frontiers in Aging Neuroscience; 2024, p1-12, 12p |
Abstrakt: | Introduction: Visual hallucination is a prevalent psychiatric disorder characterized by the occurrence of false visual perceptions due to misinterpretation in the brain. Individuals with Parkinson's disease often experience both minor and complex visual hallucinations. The underlying mechanism of complex visual hallucinations in Parkinson's patients is commonly attributed to dysfunction in the visual pathway and attention network. However, there is limited research on the mechanism of minor hallucinations. Methods: To address this gap, we conducted an experiment involving 13 Parkinson's patients with minor hallucinations, 13 Parkinson's patients without hallucinations, and 13 healthy elderly individuals. We collected and analyzed EEG and MRI data. Furthermore, we utilized EEG data from abnormal brain regions to train a machine learning model to determine whether the abnormal EEG data were associated with minor hallucinations. Results: Our findings revealed that Parkinson's patients with minor hallucinations exhibited excessive activation of cortical excitability, an imbalanced interaction between the attention network and the default network, and disruption in the connection between these networks. These findings is similar to the mechanism observed in complex visual hallucinations. The visual reconstruction of one patient experiencing hallucinations yields results that differ from those observed in subjects without such symptoms. Discussion: The visual reconstruction results demonstrated significant differences between Parkinson's patients with hallucinations and healthy subjects. This suggests that visual reconstruction techniques may offer a means of evaluating hallucinations. [ABSTRACT FROM AUTHOR] |
Databáze: | Complementary Index |
Externí odkaz: |