| Autor: |
Harary, Maya, Fernandez, Elizabeth, Casaos, Joshua, Vitte, Jeremie, Nathanson, David, Na, Brian, Prins, Robert, Giovannini, Marco, Everson, Richard |
| Předmět: |
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| Zdroj: |
Journal of Neurological Surgery. Part B. Skull Base; 2024 Supplement, Vol. 85, pS1-S398, 398p |
| Abstrakt: |
This article, published in the Journal of Neurological Surgery, explores the potential use of basal BCL-2-interacting mediator of cell death (BIM) responsiveness as a predictor of radiosensitivity in meningioma. The study used an in vitro model of meningioma to investigate the correlation between BIM-responsiveness and radiosensitivity. The results showed a wide range of radiosensitivities and basal apoptotic sensitivities in the meningioma cells. The study suggests that targeting BCL-XL and MCL-1, which are involved in apoptotic resistance, may enhance radiosensitivity in meningioma. Further research is needed to understand the mechanisms of apoptosis-evasion and radio-resistance in meningioma. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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