| Autor: |
Patel, Bhuvic, Barrett, Thomas F., Khan, Saad M., Mullens, Riley, Yim, Aldrin K., Pugazenthi, Sangami, Mahlokozera, Tatenda, Zipfel, Gregory J., Herzog, Jacques A., Chicoine, Michael R., Wick, Cameron C., Durakovic, Nedim, Osbun, Joshua W., Shew, Matthew, Sweeney, Alex D., Patel, Akash J., Buchman, Craig A., Petti, Allegra A., Puram, Sidharth V., Kim, Albert H. |
| Předmět: |
|
| Zdroj: |
Journal of Neurological Surgery. Part B. Skull Base; 2024 Supplement, Vol. 85, pS1-S398, 398p |
| Abstrakt: |
This article explores the pathophysiology of sporadic vestibular schwannomas (VS), which are benign tumors that can cause neurological and otological issues. The study used single cell RNA sequencing, ATAC sequencing, and whole exome sequencing to analyze the tumor microenvironment (TME) of VS. The findings revealed diverse populations of tumor Schwann cells, stromal cells, and immune cells within the TME. The researchers identified two molecular subtypes of sporadic VS, with the "Injury-like" subtype being enriched for myeloid cells and potentially driven by recruitment of these cells via CSF1 signaling. These findings provide insights into potential molecular targets for treating sporadic VS. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
