Clinicopathological Characteristics and Prognosis of Diffuse Large B-Cell Lymphoma in Relation to CA-125 andCA19-9Expression.
| Autor: | Foda, Abd AlRahman Mohammad, Atia, Tarek, Sakr, Hader I., Ahmed Elnaghi, Khaled Abd Elaziz, Abdelhay, Wagih M., Enan, Eman T. |
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| Předmět: |
STAINS & staining (Microscopy)
IMMUNOHISTOCHEMISTRY LOG-rank test B cell lymphoma GENE expression SEX distribution SYMPTOMS SURVIVAL analysis (Biometry) DESCRIPTIVE statistics KAPLAN-Meier estimator CHI-squared test TUMOR antigens TUMOR markers PROGRESSION-free survival DATA analysis software OVERALL survival NON-Hodgkin's lymphoma |
| Zdroj: | Journal of Evidence-Based Integrative Medicine; Jan-Dec2023, Vol. 28, p1-8, 8p |
| Abstrakt: | Background: Some epithelial tumors express the carbohydrate antigen 125 (Cancer antigen-125, CA-125) andCA19-9, especially ovarian and pancreatic tumors. Patients with non-Hodgkin lymphoma (NHL)were reported to have a close association between serumCA-125 levels and adverse prognostic factors with worse survival. We aimed to investigate CA-125 and 19-9 expression in nodal diffuse large B-cell lymphoma, not otherwise specified (DLBCL NOS) tissues using immunohistochemistry (IHC) and their relations to clinicopathologicalmanifestations and patients' survival. Methods: 65 cases of DLBCL NOS were examined. A modified mechanical pencil tip was used to construct Manual Tissue Micro-array (TMA) blocks. Immunohistochemical staining for CA-125 and CA 19-9 was performed and scored semi-quantitatively. All relationswere analyzed using established statistical methodologies. Results: Aberrant expression of CA19-9was detected in 12% of caseswithout any expression of CA-125. Moreover, 75%of theCA19-9 positive caseswere statistically significantly associated with anemia and performance status 1. Also, 75% of the CA 19-9 positive caseswere females. Conclusions:CA19-9 was aberrantly expressed in 12% of nodal DLBCL NOS cases and significantly related to anaemia and performance status but not to survival. In cases of DLBCL NOS, CA 19-9 expression cannot be considered an independent prognostic factor.CA-125 was not expressed in nodalDLBCLNOStissues, necessitating reevaluation studies. Therefore, it is advised to conduct more research to clarify the potential correlation between serum and tissue CA 19-9 levels and other clinic-pathological characteristics of nodal and extranodal DLBCL NOS patients. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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