Opioid and Non-Opioid Pharmacotherapy Use for Pain Management Among Privately Insured Pediatric Patients With Cancer in the United States.
| Autor: | Shen, Chan, Thornton, J Douglas, Li, Ning, Schaefer, Eric, Zhou, Shouhao, Kawasaki, Sarah, Pameijer, Colette, Leslie, Douglas |
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| Předmět: |
LYMPHOMA diagnosis
LEUKEMIA diagnosis ANTICONVULSANTS ANTIDEPRESSANTS MUSCLE relaxants CONFIDENCE intervals NONOPIOID analgesics NONSTEROIDAL anti-inflammatory agents MULTIVARIATE analysis PEDIATRICS CANCER patients BONE tumors DRUGS HEALTH insurance RESEARCH funding DRUG utilization OPIOID analgesics MEDICAL prescriptions LOGISTIC regression analysis ODDS ratio CENTRAL nervous system PAIN management CHILDREN |
| Zdroj: | Oncologist; Feb2024, Vol. 29 Issue 2, p176-184, 9p |
| Abstrakt: | Background This study examined the trends and patterns of opioid and non-opioid pharmacotherapy use among a large national sample of privately insured pediatric patients with cancer in the United States. Materials and Methods We identified pediatric (aged < 21) patients diagnosed with central nervous system (CNS), lymphoma, gonadal, leukemia, or bone cancer from MarketScan data 2005-2019. We examined the proportion of patients who filled a prescription for the following 5 types of pharmacotherapy: opioid, anticonvulsant, non-steroidal anti-inflammatory drug (NSAID), antidepressant, and muscle relaxant during active cancer treatment. We assessed the trends and patterns in pharmacotherapy using multivariable logistic regressions. Results Among 4174 patients included, 2979 (71%) had an opioid prescription; 746 (18%), 384 (9%), 202 (5%), and 169 (4%) had anticonvulsant, NSAID, antidepressant and muscle relaxant prescriptions, respectively. Multivariable logistic regression showed a nonlinear trend in the use of opioids among pediatric patients with cancer over time such that use slightly increased until 2012 (OR of 1.40 [95% CI, 1.12-1.73] for 2012 vs. 2006) but then decreased thereafter (OR of 0.51 [0.37-0.68] for 2018 vs. 2012). The use of anticonvulsants, NSAIDs, and muscle relaxants increased significantly linearly over time (all P < .005). Conclusion There has been a downward trend in the use of opioids in recent years among pediatric patients with cancer and an upward trend in the use of non-opioid pharmacotherapy for pain management potentially as an alternative to opioids. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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