VEGF-A-induced changes in distal outflow tract structure and function.

Autor: Oltmann, Jannis, Morell, Mark, Dakroub, Mohamad, Verma-Fuehring, Raoul, Hillenkamp, Jost, Loewen, Nils
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Zdroj: Graefe's Archive of Clinical & Experimental Ophthalmology; Feb2024, Vol. 262 Issue 2, p537-543, 7p
Abstrakt: Purpose: To investigate changes in distal outflow tract vessels caused by VEGF-A and their impact on outflow. Methods: We compared VEGF-A perfused porcine anterior segments with and without trabecular meshwork (TM) to control eyes. In the first experiment (n=48), we analyzed live changes of the outflow tract with spectral-domain optical coherence tomography (SD-OCT) over 3 h and reconstructed them in 3D. In a second experiment (n=32), we measured the intraocular pressure (IOP) variation in response to VEGF-A over 48 h and computed the outflow facility. Results: VEGF-A increased the vessel volume of the distal outflow tract by 16.8±10.6% while control eyes remained unchanged (0.5±6.8%). Volume changes occurred within the first 100 min before plateauing at 140 min. VEGF-A enhanced the outflow facility in eyes without TM by 38.6±25.5% at 24 h as compared to controls (p<0.05). Conclusion: VEGF-A dilated vessels of the distal outflow tract and increased the outflow facility even after TM removal, pointing to a regulatory mechanism independent of proximal structures. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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