| Autor: |
De la Cerda-Vargas, Maria F., Candelas-Rangel, Jose A., Navarro-Dominguez, Pedro, Sandoval-Bonilla, Bayron A., Meza-Mata, Elizabeth, Muñoz-Hernandez, Melisa A., Segura-Lopez, F. K., Ramirez-Silva, Luis H., Gonzalez-Martinez, Marisela Del Rocio, Delgado-Aguirre, Hector A. |
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| Zdroj: |
Child's Nervous System; Feb2024, Vol. 40 Issue 2, p303-319, 17p |
| Abstrakt: |
Purpose: Coccidioidal meningitis (CM) is an uncommon disease frequently misdiagnosed. Neuroimaging and mortality are not considered in detail in previous pediatric CM series. Our objective is to evaluate outcome of pediatric neurococcidiomycosis in relation to neuroimaging findings. Methods: We performed a prospective, observational, cross-sectional study in children with hydrocephalus and CM treated at Specialties Hospital in Torreon, Mexico (between 2015 and 2020). The outcome was evaluated by Hydrocephalus Outcome Questionnaire (HOQ) and the modified Rankin Scale (mRS). Follow-up was established at the first shunt surgery and survival since CM diagnosis confirmation. Neuroimaging was analyzed in relation to clinical data, outcome and survival. Kaplan-Meier analysis was performed with IBM-SPSS-25. Results: Ten pediatric cases with CM and hydrocephalus were reported. Aged 6–228 months, 60% were female. Mean number of surgeries was 4.3 SD ± 3 (range 1–15). Asymmetric hydrocephalus was the most common neuroimaging finding (70%), followed by cerebral vasculitis (20%) and isolated fourth ventricle (IFV) (20%). The mean HOQ overall score was 0.338 SD ± 0.35. A minimum follow-up of 18 months was reported. Mean survival was 13.9 SD ± 6.15 months (range 3–24). Poor survival was correlated with asymmetric hydrocephalus (p = 0.335), cerebral vasculitis (p = 0.176), IFV (p < 0.001), bacterial superinfection (p = 0.017), lower mRS scores at hospital discharge (p = 0.017) and during follow-up (p = 0.004). The mortality rate was 20%. Conclusions: We report the largest series in Latin America of pediatric CM and hydrocephalus. Asymmetric hydrocephalus, IFV and cerebral vasculitis are complications that increase mortality and must be early diagnosed for a timely surgical and medical treatment. HOQ and mRS could be alternative scales to evaluate outcome in these patients. After a long follow-up (18 months), survival remained poor after diagnosis confirmation in our series. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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