| Autor: |
Yuka Takada, Katsuya Kishikawa, Takeshi Hojo, Yasunari Nodax, Masahiko Tokushima, Takeshi Nagamatsu |
| Předmět: |
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| Zdroj: |
Pharmacometrics / Ōyō Yakuri (0300-8533); Dec2023, Vol. 105 Issue 3/4, p57-68, 12p |
| Abstrakt: |
A recent clinical trial reported that dietary supplementation with docosahexaenoic acid (DHA) improved seminal antioxidant status and decreased sperm DNA fragmentation. To determine the effects of the intake of dietary supplements containing 150 mg of DHA and 60 mg of eicosapentaenoic acid (EPA) derived from salmon roe oil on sperm. We performed a randomized, double-blinded, placebo-controlled trial between February 2020 and November 2020. Healthy males (110) aged 35-65 years were randomly assigned to two groups in a 1:1 ratio for 12 weeks. Those in the intervention group (n = 55) received 1000 mg of salmon roe oil (containing 150 mg of DHA and 60 mg of EPA), whereas those in the control group (n = 55) received the placebo (safflower oil). The primary endpoint was the influence on semen analysis, and the secondary endpoints were alterations in health-related quality (evaluated using a 36-item short-form health survey, Profile of Mood States. Second Edition-Adult Short, post-intake questionnaire, luteinizing hormone, follicle-stimulating hormone, and testosterone). Salmon roe oil-derived DHA and EPA supplements increased sperm concentrations in males aged 35-44 years. No significant differences were observed in any item of the semen analysis or secondary endpoints. In the subgroup analysis of the primary endpoint (semen analysis) by age, the change in sperm concentration in individuals aged 35-44 years was significantly increased in the intervention group as compared with that in the placebo group. There were no significant changes in sperm concentration in individuals aged 45-65 years. The sperm concentration after 12 weeks in the 35-14 years group significantly increased in the intervention group as compared with that in the placebo group. Whether this increase is associated with fertility requires further clinical investigation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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