Recent Findings from University of California Davis Provides New Insights into Proinsulin (Paracrine Signalling By Pancreatic D Cells Determines the Glycaemic Set Point In Mice).

Předmět:	POINT set theory PROINSULIN MOLECULAR biology PEPTIDE hormones LIFE sciences INSULIN aspart
Zdroj:	Gastroenterology Week; 2/5/2024, p508-508, 1p
Abstrakt:	A recent study conducted at the University of California Davis examined the role of delta cells and somatostatin (SST) secretion in glucose homeostasis. The researchers found that ablating delta cells or SST led to a sustained decrease in the glycaemic set point in mice. This reduction coincided with a decreased glucose threshold for insulin response from beta cells, resulting in increased insulin secretion. The study suggests that delta cells provide tonic feedback inhibition that lowers the glycaemic set point in vivo. The research has been peer-reviewed and published in Nature Metabolism. [Extracted from the article]
Databáze:	Complementary Index
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