Synthesis and anti-inflammatory activity of 4-aryl-2-[(3-cyanothiophen-2-yl)amino]-4-oxobut-2-enoates.

Autor: Sharavyeva, Yu. O., Gorbunova, I. A., Makhmudov, R. R., Shipilovskikh, D. A., Silaichev, P. S., Shipilovskikh, S. A.
Zdroj: Russian Chemical Bulletin; Dec2023, Vol. 72 Issue 12, p3005-3012, 8p
Abstrakt: 4-Aryl-4-oxo-2-(thiophen-2-ylamino)but-2-enoates bearing a cyano functional group at the thiophene ring were synthesized by the reaction of the corresponding substituted 3-(thiophen-2-ylamino)-3H-furan-2-ones with primary alcohols. Evaluation of biological activity and acute toxicity of the synthesized esters revealed their pronounced anti-inflammatory effect and low toxicity. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index