Cyclization of ethyl 4,4,4-trifluoroacetoacetate and cycloheptanone with dinucleophiles in the design of new alkaloid-like structures.

Autor:	Kushch, S. O., Goryaeva, M. V., Burgart, Ya. V., Saloutin, V. I.
Zdroj:	Russian Chemical Bulletin; Dec2023, Vol. 72 Issue 12, p2889-2897, 9p
Abstrakt:	Three-component cyclization of ethyl 4,4,4-trifluoroacetoacetate and cycloheptanone with 1,2-diamines, 1,3-diamines, and 1,2-aminoalcohols leads to previously unknown types of tricyclic azaheterocyclic structures, which are trifluoromethyl-substituted cyclo-hepta-annulated derivatives of imidazo[1,2-a]-, oxazolo[3,2-a]pyridin-5-ones, pyrido[1,2-a]-pyrimidin-6-one, and pyrido[2,1-b]quinazolin-8-one. The structure of these diastereomeric heterocycles was established, and the mechanism of their formation was proposed. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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