Insight into the significance of CD8+ tumor‐infiltrating lymphocytes in squamous cell lung cancer.

Autor:	Shiomi, Kazu, Ichinoe, Masaaki, Ushiwata, Ai, Eshima, Koji, Nagashio, Ryo, Hayashi, Shoko, Sonoda, Dai, Kondo, Yasuto, Maruyama, Raito, Mikubo, Masashi, Murakumo, Yoshiki, Satoh, Yukitoshi
Předmět:	EPITHELIAL cell tumors RESEARCH BIOMARKERS CONFIDENCE intervals IMMUNE checkpoint inhibitors IMMUNOHISTOCHEMISTRY LUNG tumors LYMPHOCYTES KAPLAN-Meier estimator SURVIVAL analysis (Biometry) DESCRIPTIVE statistics T cells PROGRESSION-free survival IMMUNOTHERAPY PROPORTIONAL hazards models PHENOTYPES
Zdroj:	Thoracic Cancer; Feb2024, Vol. 15 Issue 4, p299-306, 8p
Abstrakt:	Background: Although there are great expectations regarding the use of tumor‐infiltrating lymphocytes (TILs) to predict effects of immunotherapies and prognosis, knowledge about TILs remains insufficient for clinical application. Methods: We objectively investigated the prognostic significance of tumor‐infiltrating CD8 + lymphocytes (CD8 + TILs) in squamous cell lung cancer (SQ‐LC). Among patients who underwent surgical resection of SQ‐LC in 2011–2017, 100 patients with pathological stage IA3‐III were immunohistochemically studied to evaluate CD8 + TILs in the tumor stroma and parenchyma. The impact of CD8 + TILs on relapse‐free survival was analyzed using a Kaplan–Meier survival analysis and multivariate analyses using Fine‐Gray and Cox proportional hazards models. Results: The multivariate analysis showed that large and small numbers, but not intermediate numbers, of CD8 + TILs in the tumor stroma may be related to a more favorable prognosis (small vs. intermediate: HR, 0.64; 95% CI: 0.29–1.41, p = 0.27; large vs. intermediate: HR, 0.48; 95% CI: 0.21–1.09, p = 0.08). In contrast, a large number of CD8 + TILs in the tumor parenchyma was associated with a poor prognosis (HR, 2.60; 95% CI: 0.91–7.42, p = 0.075). An exploratory analysis showed a potentially strong association between an extremely large number of CD8 + TILs in the tumor parenchyma and a poor prognosis, even with a large number of CD8 + TILs in the tumor stroma. Conclusion: Our study provided partial but important information on the significance of CD8 + TILs in SQ‐LC. To use CD8 + TILs as biomarkers, a better understanding of CD8 + TILs as well as other important components in the tumor microenvironment and the inflammatory phenotypes they form may be needed. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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