| Autor: |
Focken, Alex P., Woodsworth, Jordan M., Loewen, Jennifer M. |
| Předmět: |
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| Zdroj: |
Journal of Veterinary Emergency & Critical Care; Jan2024, Vol. 34 Issue 1, p57-62, 6p |
| Abstrakt: |
Objective: To assess the ability of intranasal atipamezole to reverse sedative effects of xylazine in dogs. Design: Prospective proof‐of‐concept study. Setting: University research laboratory. Animal: Six healthy, staff‐owned dogs. Interventions: Dogs were sedated with 1.1 mg/kg of xylazine intravenously. The sedation score of each dog was recorded every 5 minutes until they achieved a sedation score of >13/21 for 3 readings. Once achieved, 0.3 mg/kg of atipamezole was administered intranasally using a mucosal atomization device. Sedation scores continued to be recorded every 5 minutes until successful reversal was achieved (<4/21). Measurements and Main Results: Average times to standing and normal wakefulness after administration of intranasal atipamezole were 6 minutes, 30 seconds and 7 minutes, 20 seconds, respectively. Conclusions: Intranasal atipamezole successfully reversed the sedation effects of xylazine. The findings of this study provide justification for future controlled prospective studies into the potential use of intranasal atipamezole in a variety of settings including exposure to xylazine in operational canines as well as bioavailability studies for optimal dosing. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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