| Autor: |
Usuki, Kensuke, Ohtake, Shigeki, Honda, Sumihisa, Matsuda, Mitsuhiro, Wakita, Atsushi, Nawa, Yuichiro, Takase, Ken, Maeda, Akio, Sezaki, Nobuo, Yokoyama, Hisayuki, Takada, Satoru, Hirano, Daiki, Tomikawa, Tatsuki, Sumi, Masahiko, Yano, Shingo, Handa, Hiroshi, Ota, Shuichi, Fujita, Hiroyuki, Fujimaki, Katsumichi, Mugitani, Atsuko |
| Zdroj: |
International Journal of Hematology; Feb2024, Vol. 119 Issue 2, p130-145, 16p |
| Abstrakt: |
We conducted a multicenter, prospective observational study of acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), and chronic myelomonocytic leukemia (CMML) in Japan. From August 2011 to January 2016, we enrolled 6568 patients. Herein, we report the results for MDS (n = 2747) and CMML (n = 182). The percentage of patients aged 65 years or older was 79.5% for MDS and 79.7% for CMML. The estimated overall survival (OS) rate and cumulative incidence of AML evolution at 5 years were 32.3% (95% confidence interval: 30.2–34.5%) and 25.7% (23.9–27.6%) for MDS, and 15.0% (8.9–22.7%) and 39.4% (31.1–47.6%) for CMML. Both diseases were more common in men. The most common treatment for MDS was azacitidine, which was used in 45.4% of higher-risk and 12.7% of lower-risk MDS patients. The 5-year OS rate after treatment with azacitidine was 12.1% (9.5–15.1%) for of higher-risk MDS patients and 33.9% (25.6–42.4%) for lower-risk patients. The second most common treatment was erythropoiesis-stimulating agents, given to just 20% of lower-risk patients. This is the first paper presenting large-scale, Japanese data on survival and clinical characteristics in patients with MDS and CMML. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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