| Autor: |
Malinverno, Matteo, Carta, Mario, Epis, Roberta, Marcello, Elena, Verpelli, Chiara, Cattabeni, Flaminio, Sala, Carlo, Mulle, Christophe, Luca, Monica Di, Gardoni, Fabrizio |
| Zdroj: |
Journal of Neuroscience; 12/1/2010, Vol. 30 Issue 48, p16343-16355, 13p, 2 Color Photographs, 4 Black and White Photographs, 4 Graphs |
| Abstrakt: |
N-Cadherin has an important role during dendrite arborization, axon guidance, and synaptogenesis. In particular, at synaptic sites, N-cadherin is involved in the regulation of cell-cell adhesion and in morphology and plasticity control. Recent studies have shown that N-cadherin can be cleaved by the metalloproteinase ADAM10. Here we demonstrate that impairing ADAM10 localization and activity at synaptic sites decreases its processing of N-cadherin. This leads to an accumulation of the full-length form of N-cadherin, to an increase in spine head width, and to modifications of the number and function of glutamate receptors of AMPA type, both in vitro and in vivo. Our results indicate a key role for ADAM10 in the complex sequence of events through which N-cadherin affects spine maturation and controls structure and function of glutamatergic synapses. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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