| Autor: |
Ye, Zhi-Xian, Bi, Jin, Qiu, Liang-Liang, Chen, Xuan-Yu, Li, Meng-Cheng, Chen, Xin-Yuan, Qiu, Yu-Sen, Yuan, Ru-Ying, Yu, Xin-Tong, Huang, Chun-Yu, Cheng, Bi, Lin, Wei, Chen, Wan-Jin, Hu, Jian-Ping, Fu, Ying, Wang, Ning, Gan, Shi-Rui |
| Předmět: |
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| Zdroj: |
Journal of Neurology; Feb2024, Vol. 271 Issue 2, p918-928, 11p |
| Abstrakt: |
Background: Many neuroscience and neurology studies have forced a reconsideration of the traditional motor-related scope of cerebellar function, which has now expanded to include various cognitive functions. Spinocerebellar ataxia type 3 (SCA3; the most common hereditary ataxia) is neuropathologically characterized by cerebellar atrophy and frequently presents with cognitive impairment. Objective: To characterize cognitive impairment in SCA3 and investigate the cerebellum–cognition associations. Methods: This prospective, cross-sectional cohort study recruited 126 SCA3 patients and 41 healthy control individuals (HCs). Participants underwent a brain 3D T1-weighted images as well as neuropsychological tests. Voxel-based morphometry (VBM) and region of interest (ROI) approaches were performed on the 3D T1-weighted images. CERES was used to automatically segment cerebellums. Patients were grouped into cognitively impaired (CI) and cognitively preserved (CP), and clinical and MRI parameters were compared. Multivariable regression models were fitted to examine associations between cerebellar microstructural alterations and cognitive domain impairments. Results: Compared to HCs, SCA3 patients showed cognitive domain impairments in information processing speed, verbal memory, executive function, and visuospatial perception. Between CI and CP subgroups, the CI subgroup was older and had lower education, as well as higher severity scores. VBM and ROI analyses revealed volume loss in cerebellar bilateral lobule VI, right lobule Crus I, and right lobule IV of the CI subgroup, and all these cerebellar lobules were associated with the above cognitive domain impairments. Conclusions: Our findings demonstrate the multiple cognitive domain impairments in SCA3 patients and indicate the responsible cerebellar lobules for the impaired cognitive domain(s). [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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