Sex differences in the association between d-dimer and the incidence of acute kidney injury in patients admitted with ST-segment elevation myocardial infarction: a retrospective observational study.

Autor: Zhou, Xi, Wang, Dingzhou, Jin, Youkai, Gong, Mengge, Lin, Qingcheng, He, Yanlei, Huang, Weijian, Shan, Peiren, Liang, Dongjie
Zdroj: Internal & Emergency Medicine; Jan2024, Vol. 19 Issue 1, p91-98, 8p
Abstrakt: Identifying the predictors of acute kidney injury (AKI) in patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI) remains important. We aimed to investigate the predictive value of d-dimer levels for the incidence of AKI in such a population, with particular attention paid to sex differences. A total of 2668 patients with STEMI who underwent PPCI were retrospectively included in this study and divided into quartiles according to their plasma d-dimer levels upon admission (Q1: < 0.36; Q2: 0.36–0.67; Q3: 0.68–1.17; Q4: > 1.17 mg/L). The primary endpoint was the occurrence of AKI during hospitalization. AKI was observed in 503 (18.8%) patients. The mean age of the patients was 63.0 ± 13.2 years, 2155 (80.8%) of whom were men. Multivariate analysis indicated that higher d-dimer levels were associated with a significantly increased risk of AKI (Q4 vs. Q1: OR: 1.57; 95% CI 1.11–2.23; P = 0.011). However, the prognostic effect of d-dimer was only observed in male patients (Q4 vs. Q1: OR: 2.07; 95% CI 1.37–3.13; P < 0.001), not in female patients (Q4 vs. Q1: OR: 0.72; 95% CI 0.37–1.41; P = 0.342) (P for interaction = 0.003). We demonstrated a notable sex difference in the association between d-dimer level upon admission and AKI in a large STEMI patient sample. A higher d-dimer level was associated with an increased risk of AKI in male patients but not in female patients. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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