| Autor: |
Jung, Jaehyun, Kinoshita, Takumi, Makihara, Yuta, Sakakibara, Yota, Amaike, Kazuma, Murakami, Kei, Itami, Kenichiro |
| Předmět: |
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| Zdroj: |
Synlett; Feb2024, Vol. 35 Issue 3, p337-341, 5p |
| Abstrakt: |
This article presents a study on the synthesis of primary benzylamines, which are important in medicinal chemistry. The researchers used a photoredox-catalyzed decarboxylative coupling method with aryl halides and glycine derivatives to create these molecules. They discuss the reaction mechanism and provide experimental results, including different reaction conditions and yields. This research contributes to the development of new synthetic procedures for primary benzylamine scaffolds, which could lead to the discovery of new functional molecules. Additionally, the study explores the decarboxylative aminomethylation of aryl bromides with glycine derivatives, testing various reaction conditions and catalysts to optimize product yield. The researchers found that electron-deficient aryl bromides reacted well, and the reaction was applicable to other heteroarenes. They also investigated the impact of different protecting groups on the nitrogen atom. Overall, this study offers an efficient method for synthesizing aminomethylated compounds, which may have potential applications in drug discovery. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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