| Autor: |
Moser, Claus, Jensen, Peter Ø, Pressler, Tacjana, Frederiksen, Birgitte, Lanng, Susanne, Kharazmi, Arsalan, Koch, Christian, Høiby, Niels |
| Předmět: |
|
| Zdroj: |
APMIS; Jun2005, Vol. 113 Issue 6, p400-409, 10p, 2 Charts, 5 Graphs |
| Abstrakt: |
Moser C, Jensen PØ, Pressler T, Frederiksen B, Lanng S, Kharazmi A, Koch C, Høiby N. Serum concentrations of GM-CSF and G-CSF correlate with the Th1/Th2 cytokine response in cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infection. APMIS 2005;113:400–9. The inflammation in cystic fibrosis (CF) patients with chronic Pseudomonas aeruginosa lung infection is dominated by polymorphonuclear neutrophils (PMNs). There seems to be a relationship between the PMN-dominated inflammation, pronounced antibody production and a Th2-dominated response. Apart from mobilizing monocytes and PMNs from the bone marrow, GM-CSF, G-CSF and IL-3 select subsets of dendritic cells, which subsequently induce distinct Th responses. Therefore, the present study examines the correlation between the mobilizing cytokines in serum and the Th responses. The IFN-γ and IL-4 production by peripheral blood mononuclear cells, and the concentrations of GM-CSF and G-CSF in serum as well as lung function, were determined in 37 CF patients with and 6 CF patients without chronic P. aeruginosa lung infection. The GM-CSF/G-CSF ratio correlated both with the IFN-γ production and good lung function. In addition, an inverse correlation between IL-3 and IFN-γ was observed. The results indicate involvement of endogenous GM-CSF, G-CSF and IL-3 in the skewed Th response in CF, and change to a Th1-dominated response might be achieved with GM-CSF treatment. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
