Photo- and X-ray Induced Cytotoxicity of CeF 3 -YF 3 -TbF 3 Nanoparticle-Polyvinylpyrrolidone—"Radachlorin" Composites for Combined Photodynamic Therapy.

Autor: Khusainova, Alina I., Nizamutdinov, Alexey S., Shamsutdinov, Nail I., Kalinichenko, Svetlana, Safin, Damir I., Gafurov, Marat, Lukinova, Elena V., Batygov, Sergey Kh., Kuznetsov, Sergey V., Zinchenko, Sergey V., Zelenikhin, Pavel V., Pudovkin, Maksim
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Zdroj: Materials (1996-1944); Jan2024, Vol. 17 Issue 2, p316, 14p
Abstrakt: The Ce0.5Y0.35Tb0.15F3 nanoparticles with a CeF3 hexagonal structure were synthesized using the co-precipitation technique. The average nanoparticle diameter was 14 ± 1 nm. The luminescence decay curves of the Ce0.5Y0.35Tb0.15F3 nanoparticles (λem = 541 nm, 5D4–7F5 transition of Tb3+) conjugated with Radachlorin using polyvinylpyrrolidone coating as well as without Radachlorin were detected. Efficient nonradiative energy transfer from Tb3+ to the Radachlorin was demonstrated. The maximum energy transfer coefficients for the nanoparticles conjugated with Radachlorin via polyvinylpyrrolidone and without the coating were 82% and 55%, respectively. The average distance between the nanoparticle surface and Radachlorin was R0 = 4.5 nm. The best results for X-ray-induced cytotoxicity were observed for the NP-PVP-Rch sample at the lowest Rch concentration. In particular, after X-ray irradiation, the survival of A549 human lung carcinoma cells decreased by ~12%. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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