| Abstrakt: |
Based on the RISKESDAS in 2018 the prevalence of burns reached 1,3% of the total population of Indonesia and basen on WHO there were 195,000 cases of deaths due to burns every year. One clinical treatment for burns is to use hydrogels as wound dressing. Hydrogel wound dressing functions to absorb wound exudates, by keeping the wound moist. This study was conducted to determine the effect of adding oat extrac to the hydrogel methylcellulose-AgNPs. Hydrogel methylcellulose-AgNPs are mixed with oat extract, with an oat extract concentration of 0 wt%, 0.5 wt%, 1 wt%, 1.5 wt%, and 2 wt%. The characterization carried out included XRD crystallinity test and SEM morphology test for the characterization of AgNPs, and it was found that 10.2% of AgNPs were formed and evenly distributed AgNPs. In addition, characterization of hydrogel wound dressing was carried out which included antibacterial test, cytotoxicity test, swelling test, and antioxidant test. From the results of the analysis it was found that the best variable methylcellulose-AgNPs-oat hydrogel was a sample with an oat concentration of 2 wt%, which had a clear zone diameter of 10.35 mm and was sensitive to bacteria, had a% viability of 2.206%, a swelling value of 71, 7%, and has an antioxidant value of 95%. It shows that the addition of oats can increase the cell viability because oats are antioxidants, so they can counteract the free radicals produced by AgNPs, but the addition of oats increases sensitivity to bacteria because oats also function as antibacterial. Samples with oats of 2 wt% have the best characterization even though they have not met the standard wound dressing. [ABSTRACT FROM AUTHOR] |
