| Autor: |
de Moraes Segundo, João de Deus Pereira, Calais, Guilherme Bedeschi, Constantino, Jamilly Salustiano Ferreira, de Moura Junior, Celso Fidelis, de Souza, Francisco Fábio Pereira, Andrade, Fábia Karine, de Moraes, Maria Oneide Silva, d'Ávila, Marcos Akira, Tsukamoto, Junko, Arns, Clarice Weis, Beppu, Marisa Masumi, Vieira, Rodrigo Silveira |
| Předmět: |
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| Zdroj: |
Polymers for Advanced Technologies; Jan2024, Vol. 35 Issue 1, p1-12, 12p |
| Abstrakt: |
This work investigated the virucidal property of copper‐loaded poly(ε‐caprolactone) (PCL)/polyvinylpyrrolidone (PVP) blended nanofibers against coronavirus. Electrospinning solutions were prepared with 0.25, 0.75, and 1.50% [w/v] of copper salt and their properties of electrical conductivity, surface tension, and viscosity were measured. The copper‐PCL/PVP nanofibers produced electrospun composite membranes of 30.5–38 g m−2. IR spectra confirmed the blended PCL/PVP, and SEM/EDS images revealed the morphology of the randomly oriented nanofibers with homogeneously incorporated copper in the electrospun nanofibers. The copper quantification indicated the final incorporation of 5.50 ± 0.31, 14.00 ± 1.03, and 27.10 ± 3.00 mg g−1 of copper, as measured by atomic absorption spectrometry, into electrospun composite membranes for 0.25, 0.75, and 1.50% [w/v] copper solution formulations, respectively, and these compositions also affected the nanofibers mechanical properties. Copper release assays showed that copper‐PCL/PVP nanofibers readily release ions into aqueous media. The 0.75% copper‐PCL/PVP composite membrane was virucidal against coronavirus, reaching 99.99% inactivation in 1 hour and 99.999% inactivation in 24 h, and non‐cytotoxic to L929 cells in 24 h of exposure. This work presents a virucidal composite membrane with potential use in personal protective equipment against viral outbreaks or pandemics. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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