| Autor: |
Van, PCong Pham, Ngo Van, Hieu, Quang, Minh Bui, Duong Thanh, Nam, Nguyen Van, Dan, Thanh, Tuan Do, Tran Minh, Ngoc, Thi Thu, Hien Nguyen, Quang, Trung Nguyen, Thao Do, Thi, Thanh, Loan Pham, Do Thi Thu, Hien, Le Tuan, Anh Hoang |
| Předmět: |
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| Zdroj: |
Natural Product Research; 2024, Vol. 38 Issue 4, p601-606, 6p |
| Abstrakt: |
Two new vernonioside K (1) and vernonioside L (2) and four known Δ7,9(11) stigmastane-type steroidal saponins—vernonioside B2 (3), vernoniacum B (4), vernonioside B1 (5), and vernoamyoside A (6)—were isolated from the leaves of Vernonia amygdalina. Their structures were determined by comprehensive spectroscopic analysis with one-dimensional nuclear magnetic resonance, two-dimensional nuclear magnetic resonance, and high-resolution mass spectrometry. All isolated compounds (1–6) were evaluated to determine their inhibitory effects on α-glucosidase and xanthine oxidase. Among them, two new compounds 1 and 2 showed significant inhibition of α-glucosidase with IC50 values of 78.56 ± 7.28 and 14.74 ± 1.57 (μM), respectively, comparable with acarbose as a positive control (127.53 ± 1.73 μM); none of these compounds inhibited xanthine oxidase activity. Compounds 1 and 2 are promising candidates for the development of antidiabetic agents from natural sources. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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