Tracking the cellular immune response from early premalignancy to active multiple myeloma in a new model.

Autor: Jadhav, Suchita Suryakant, Luboshits, Galia, Bogen, Bjarne, Firer, Michael A.
Předmět:
Zdroj: European Journal of Immunology; Jan2024, Vol. 54 Issue 1, p1-3, 3p
Abstrakt: A study published in the European Journal of Immunology describes the development of a murine model to study the progression of multiple myeloma, an incurable cancer of plasma cells. The model successfully mirrors the development of clinical multiple myeloma and demonstrates changes in the immune profile over time. The study highlights the involvement of immune cell subtypes in tumor immune escape and disease progression, providing insights for the development of novel immunotherapies. The model can be used to investigate the breakdown of immunosurveillance and immunosuppression in the early stages of multiple myeloma, potentially accelerating the development of new treatments. [Extracted from the article]
Databáze: Complementary Index