| Abstrakt: |
A recent study conducted by researchers at the Hebrew University of Jerusalem explores the role of the exostosin glycosyltransferase 1 (EXT1) enzyme in breast cancer aggressiveness. The study found that EXT1 is upregulated in aggressive tumor subtypes and cancer cell lines, and its expression is associated with enhanced epithelial-mesenchymal transition (EMT) features, such as cell migration, invasion, and tumor formation. The researchers also discovered that EXT1 regulates signal transducer and activator of transcription 3 (STAT3) signaling, a known regulator of cancer cell aggressiveness. These findings suggest that the EXT1/HSPG/STAT3 axis may serve as a central regulator of cancer cell plasticity and provide insights into potential therapeutic targets for breast cancer treatment. [Extracted from the article] |
