| Autor: |
Sakai, Akari, Shinkuma, Satoru, Miura, Nobuaki, Deguchi, Tokiko, Oginezawa, Mahoko, Nakajima, Mami, Katsumi, Tatsuya, Hayashi, Ryota, Abe, Riichiro |
| Předmět: |
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| Zdroj: |
British Journal of Dermatology; Feb2024, Vol. 190 Issue 2, p272-274, 3p |
| Abstrakt: |
This article discusses a case study of a patient with Papillon-Lefèvre syndrome (PLS), a rare genetic disorder characterized by palmoplantar keratosis and severe periodontitis. The study focuses on the possible relationship between seasonal fluctuations in skin lesions and temperature-dependent cathepsin C enzymatic activity. The patient exhibited worse skin lesions in winter and improvement in summer, and had minimal dental complications. The study suggests that the remaining activity of cathepsin C may account for the seasonal fluctuations in skin lesions and minimal dental complications observed in this case. Further research is needed to confirm these findings. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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