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| Zdroj: |
Genomics & Genetics Weekly; 2/2/2024, p828-828, 1p |
| Abstrakt: |
New research conducted at the First Affiliated Hospital of Gannan Medical University explores the relationship between iron accumulation and osteoporosis. The study focuses on the effect of chronic iron accumulation induced by hepcidin1 deficiency on aging osteoporosis. The researchers found that iron accumulation caused low bone mass and deteriorated bone microarchitecture in mice, along with decreased osteogenic markers and increased oxidative stress. In vitro experiments also showed that hepcidin1 knockdown inhibited proliferation and osteogenic differentiation while promoting apoptosis. The study concludes that iron accumulation induced by hepcidin1 deficiency aggravates the progression of aging osteoporosis by inhibiting osteogenesis and promoting osteoclast genesis. [Extracted from the article] |
| Databáze: |
Complementary Index |
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