Characteristics of the Blood Protein Composition of a Healthy Human during a Year-Long Stay at the Vostok Antarctic Station.

Autor: Pastuhkova, L. Kh., Goncharova, A. G., Kashirina, D. N., Chebotok, A. N., Kononikhin, A. S., Brzhozovsky, A. G., Larina, I. M., Ilyin, E. A., Orlov, O. I.
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Zdroj: Human Physiology; Dec2023, Vol. 49 Issue 7, p825-829, 5p
Abstrakt: Chromatography–mass spectrometry analysis of samples recovered from dried blood spots obtained during a year-long stay at the Vostok Antarctic station within the 65th Russian Antarctic Expedition identified 6798 peptides with the maximum level of confidence, from which it became possible to identify 1239 different proteins. The names of proteins whose concentration changed by the 4th and 12th months of stay at the station were determined, and common proteins typical for periods of research were identified. Both period-specific and common reliable changes in the concentration of blood proteins that formed by the 4th and 12th month of stay at the station were determined by bioinformatics methods. Signaling pathways and methods of adaptation of the body when exposed to extreme conditions are discussed based on proteomics data. The data obtained suggest that the implementation of professional activities under conditions of prolonged hypobaric hypoxia, isolation, and hypokinesia at the Vostok station in Antarctica is accompanied by changes in the blood proteome, affecting primarily the processes of maintaining chemical-energy homeostasis at the molecular, cellular, tissue, organ, and systemic levels. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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