| Autor: |
Lebedeva-Georgievskaya, K. B., Perevezentsev, A. A., Kuznetsova, O. S., Kudrin, V. S., Pikalov, V. A., Mitrofanova, O. V., Masanova, A. A., Shtemberg, A. S. |
| Předmět: |
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| Zdroj: |
Human Physiology; Dec2023, Vol. 49 Issue 7, p772-779, 8p |
| Abstrakt: |
A study of molecular mechanisms of the neurobiological effects of the combined exposure to 10‑day antiorthostatic suspension (AnOS), daily γ-irradiation, and irradiation with carbon ions in rats was carried out. Analysis of molecular changes in dopamine receptors of the hippocampus revealed changes in irradiated rats; in particular, increased expression of monoamine oxidase A, the substrates of which are serotonin, adrenaline, norepinephrine and histamine, was found. The spectral and amplitude–frequency EEG characteristics of rats after the specified influences were studied. Comparison of primary EEG results revealed a tendency towards a decrease in the frequencies of the first peak in irradiated rats regardless of rhythms. In irradiated animals, a tendency towards a decrease in the center frequencies and amplitudes of the most pronounced peak of the EEG spectrum and a decrease in the center frequency and amplitude within the delta rhythm of the maximum peak of the spectrum was observed. Increased anxiety and somewhat accelerated learning in the Morris tests and conditioned reflexes of active avoidance in the shuttle chamber were observed in the behavior of rats, which was consistent with changes in some metabolites of dopamine and serotonin in the hippocampus. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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