| Autor: |
Yang, Zhan, Tang, Chengliang, Sun, Xuewei, Wu, Zihan, Zhu, Xiaojing, Cui, Qian, Zhang, Ruonan, Zhang, Xinrui, Su, Yunxin, Mao, Yinghua, Wang, Chunhui, Zheng, Feng, Zhu, Jin |
| Předmět: |
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| Zdroj: |
Annals of Microbiology; 1/26/2024, Vol. 74 Issue 1, p1-12, 12p |
| Abstrakt: |
Purpose: This research was conducted to investigate the potential of short-chain fatty acids (SCFAs) in protecting organs from heat stress-induced injuries and gut microbiota modulation. Methods: Sprague–Dawley rats were randomly assigned to various groups including a control group, a room temperature training group, a hyperthermia training group, SCFAs pretreatment group, and recipients received feces from the HT group. After strenuous training at high temperatures, the levels of plasma enzymes AST, ALT, BUN, and Cr were evaluated. The changes in gut microbiota and fecal metabolites were detected using 16S rRNA sequencing and GC–MS methods. Pathological examination of colon and liver tissues was conducted, and immunohistochemical techniques were employed to assess intestinal barrier function. Results: The findings indicate that SCFAs hold the potential for mitigating liver and colon damage caused by heat stress. With the intervention of SCFAs, there were observable changes in the structure and metabolites of the intestinal microbiota, as well as improvements in intestinal barrier function. Further support for the benefits of SCFAs was found through fecal microbiota transplantation, which demonstrated that modified gut microbiota can effectively reduce organ damage. Conclusions: This study provides evidence that SCFAs, as metabolites of the gut microbiota, have a valuable role to play in regulating gut health and mitigating the harmful effects of heat stress. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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