| Autor: |
Kolano, Agata, Pejas, Anna, Markowiak, Szymon, Wardęszkiewicz, Marta, Jabłońska, Wiktoria, Kasprzak, Amelia, Świercz, Maciej, Truchta, Monika, Mańkowska, Aleksandra |
| Předmět: |
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| Zdroj: |
Journal of Education, Health & Sport; 2024, Vol. 51, p179-197, 19p |
| Abstrakt: |
Introduction and purpose: Endometrial cancer [EC] is the most common gynecological cancer in developed countries and its incidence is increasing worldwide. Obesity is a prominent risk factor associated with its incidence and progression. The aim of study: The article aims to provide a thorough explanation of the mechanisms through which obesity can contribute to the development of EC. Additionally, it emphasizes the crucial role of combating excess adipose tissue as a significant component of cancer prevention specifically targeting endometrial cancer. Material and method: The literature review applied standard criteria and focused on PubMed articles using keywords: Endometrial cancer, Obesity, Mortality, Prevention, Pathogenesis. Description of the State of Knowledge: Obesity significantly impacts EC development and prognosis, particularly in Type I cases. It modifies adipose tissue metabolism, affecting the release of various substances linked to tumor growth and mortality risk. The relative risks escalate with increasing BMI. Following an EC diagnosis, higher BMI, especially =40, significantly associates with increased overall mortality risk. On a preventive front, exercise showcases its potential in reducing EC risk by moderating insulin and estrogen levels. Summary: These findings underscore the critical role of obesity in both EC development and prognosis, emphasizing the potential for preventive measures. Without proactive measures, the worldwide obesity epidemic will persist, exerting a substantial effect on EC occurrences. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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