Hypocalcemia in thalassemia major patients requires an extra-careful approach.

Autor: Bahadoram, Mohammad, Keikhaei, Bijan, Davoodi, Mohammad, Fard, Najmeh Nameh Goshay, Ghiasi, Pouria, Akade, Esma'il
Předmět:
Zdroj: Journal of Parathyroid Disease; 2023, Vol. 11 Issue 1, p1-2, 2p
Abstrakt: Thalassemia is a hematological disorder caused by a gene mutation that leads to defective synthesis of hemoglobin complex. One of the complications of thalassemia is hypocalcemia which is presented with paresthesia, muscle spasm, low-serum calcium, and intracranial calcification. Hypocalcemia can affect thalassemic patients via various mechanisms. Blood transfusion-related and transfusion-independent iron overload, drug side effects, vitamin D3 deficiency, and genetic disorders and polymorphisms are among the etiologies of hypocalcemia in major thalassemia. A careful approach to the differential etiology of this phenomenon is crucial for a resultful treatment. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index