| Autor: |
Tsuboi, Yuri, Shimizu, Misayo, Kuroda, Akihiro, Suyama, Takuya, Seki, Masanori, Shinagawa, Atsushi |
| Předmět: |
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| Zdroj: |
Oxford Medical Case Reports; Nov2023, Vol. 2023 Issue 11, p1-4, 4p |
| Abstrakt: |
Secondary central nervous system (CNS) relapse by aggressive non-Hodgkin's lymphoma is a well-known complication portending a very poor prognosis. Conversely, patients with indolent lymphoma-like follicular lymphoma (FL) rarely present with CNS involvement and, thus, limited information is currently available. We herein describe a patient with FL who developed CNS involvement during chemotherapy. Treatment including high-dose methotrexate and radiation therapy was ineffective and the patient died 5 months after CNS relapse. In a literature review, there were 8 case reports of the secondary CNS relapse of FL. The findings obtained suggest that bone marrow infiltration is a risk factor for CNS relapse. Moreover, 5 out of 9 patients died within 2.5 years, indicating a poorer prognosis than that of FL. Therefore, it is important to promptly perform detailed examinations as soon as neurological findings appear. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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