| Autor: |
Iannuzzi, Vincenzo, Sarno, Stefania, Sazzini, Marco, Abondio, Paolo, Sala, Claudia, Bacalini, Maria Giulia, Gentilini, Davide, Calzari, Luciano, Masciotta, Federica, Garagnani, Paolo, Castellani, Gastone, Moretti, Edgardo, Dasso, Maria Cristina, Sevini, Federica, Franceschi, Zelda Alice, Franceschi, Claudio, Pettener, Davide, Luiselli, Donata, Giuliani, Cristina |
| Předmět: |
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| Zdroj: |
Evolution, Medicine & Public Health; 2023, Vol. 11 Issue 1, p397-414, 18p |
| Abstrakt: |
Background and objectives Epigenetic estimators based on DNA methylation levels have emerged as promising biomarkers of human aging. These estimators exhibit natural variations across human groups, but data about indigenous populations remain underrepresented in research. This study aims to investigate differences in epigenetic estimators between two distinct human populations, both residing in the Gran Chaco region of Argentina, the Native-American Wichí, and admixed Criollos who are descendants of intermarriages between Native Americans and the first European colonizers, using a population genetic approach. Methodology We analyzed 24 Wichí (mean age: 39.2 ± 12.9 yo) and 24 Criollos (mean age: 41.1 ± 14.0 yo) for DNA methylation levels using the Infinium MethylationEPIC (Illumina) to calculate 16 epigenetic estimators. Additionally, we examined genome-wide genetic variation using the HumanOmniExpress BeadChip (Illumina) to gain insights into the genetic history of these populations. Results Our results indicate that Native-American Wichí are epigenetically older compared to Criollos according to five epigenetic estimators. Analyses within the Criollos population reveal that global ancestry does not influence the differences observed, while local (chromosomal) ancestry shows positive associations between specific SNPs located in genomic regions over-represented by Native-American ancestry and measures of epigenetic age acceleration (AgeAccelHannum). Furthermore, we demonstrate that differences in population ecologies also contribute to observed epigenetic differences. Conclusions and implications Overall, our study suggests that while the genomic history may partially account for the observed epigenetic differences, non-genetic factors, such as lifestyle and ecological factors, play a substantial role in the variability of epigenetic estimators, thereby contributing to variations in human epigenetic aging. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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